![]() Throughout the year 2020, scientists worked to identify, investigate, and analyze various medications in order to find a cure for this deadly sickness. ![]() Almost all academic, social, cultural, and political activity was delayed during the epidemic, and the world was put on lockdown to prevent the spread of infection. The World Health Organization (WHO) labeled this health emergency an epidemic on 11 March 2020 and recommended different precautions to avoid illness transmission. Unfortunately, the virus’s rapid spread resulted in a significant rate of mortality and morbidity over the globe. Antibiotics, anti-inflammatory medications, muscle relaxants, ant tubercular drugs, and antiviral agents are only a few of the drugs that contain this backbone. With continued interest in organic synthesis, it was desirable to identify efficient and effective synthesis methods due to their wide range of pharmacological actions. They were created with the goal of obtaining the highest chemotherapeutic effects, particularly for SBs with a heterocyclic ring. Thousands of chemical structural variants were examined after the discovery of Schiff bases. Schiff bases (SBs) with an azomethine linkage (R1–CH=N–R2) have been described as potential and adjustable compounds in drug development. ![]() The azomethine (N = CH) lone pair of electrons interact in their structure is responsible for the stability of structures with metal ions. All ligands get the interesting potential to bind with transition metals to form their respective compounds of main group, lanthanide, actinide, and transition metal elements, substantially improving their properties. In recent years, Schiff bases have been frequently used to create metallobiosite replacements in enzymes, such as catechol oxidase, galactose oxidase, superoxide dismutase, phosphatase, cytochrome P-450, urease, and phenoxazinone synthase, along with others. It’s a common choice in biomedical studies for its simplicity of synthesis as well the enrollment of imidazole moieties in medicines, proteins, and enzymes. The overview of heterocyclic compounds, which played a critical role in controlling biological activity, was the most significant achievement as in development of drug chemistry. Metal complexes have had a major impact on the formation of metallodrugs. Thus, it immediately needs to develop new biological pharmacophores blessed with a broad spectrum of activity and less toxicity. The current design and development of new antiviral agents for opposing COVID-19 is engrossed mainly on reducing the effects of the virus. Finally, the toxicity of a metal-containing inorganic complex will thus be discussed by its capability to transfer metals which may bind with targeted site. Experimental research is required to determine the pharmacokinetics of most of the complexes analyzed for the treatment of SARS-CoV-2-related disease. ![]() ![]() Molecular docking and pharmacophore studies presented that most of complexes studied influenced good binding affinity to the main protease SARS-CoV-2, which also was attained as from the RCSB pdb (Protein Data Bank) data PDB ID: 6 W41, to expect the action of metal complexes in contradiction of COVID-19. The structures of the obtained metal complexes were fully elucidated by different analytical and spectroscopic techniques also. In this regard, metal complexes have attained immense interest as antibody modifiers and antiviral therapies, and they have a lot of promise towards SARS-CoV-2 and their suggested mechanisms of action are discussed, i.e., a new series of metal complexes’ medicinal vital role in treatment of specific proteins or SARS-CoV-2 are described. Because of the advent of new coronavirus variants, it is critical to find effective treatments and vaccines to prevent the virus’s rapid spread over the world. This pandemic, which has been linked to high rates of death, has forced some countries throughout the world to implement complete lockdowns in order to contain the spread of infection. Coronavirus disease (SARS-CoV-2) is a global epidemic. ![]()
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